Population Stratification in Genetic Association Studies: Bias, Type I error and Type II Error
نویسندگان
چکیده
منابع مشابه
Robustness of case-control studies of genetic factors to population stratification: magnitude of bias and type I error.
Case-control studies of genetic factors are prone to a special form of confounding called population stratification, whenever the existence of one or more subpopulations may lead to a false association, be it positive or negative. We quantify both the bias (in terms of confounding risk ratio) and the probability of false association (type I error) in the most unfavorable situation in which only...
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We read with interest the article by de Jong and colleagues (Gut 2003;52:547–51) reporting studies of genetic associations between DNA polymorphisms in xenobiotic metabolising genes and Crohn’s disease (CD). The authors employed a case control study design to test seven polymorphisms in five candidate genes for disease association. Evidence was found for a significant association of a single nu...
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ژورنال
عنوان ژورنال: American Journal of Epidemiology
سال: 2006
ISSN: 1476-6256,0002-9262
DOI: 10.1093/aje/163.suppl_11.s84-b